Investigation of the mode of action of nematode neuropeptides
Keating, Christopher, Holden-Dye, Lindy and Walker, Robert J.
(1996)
Investigation of the mode of action of nematode neuropeptides.
pp. 263-266.
ISSN 0031-613X
The neuropeptide AF2 has a complex set of actions on the dorsal muscle strip of Ascaris suum, including a potentiation of the acetylcholine-stimulated muscle contraction. Caffeine at 100 μm and 5 mm inhibited this potentiation, as did 100 μm theophylline in two out of six studies. The cyclic-AMP-potentiating compounds IBMX, dibutyryl cAMP and forskolin had no effect on the AF2-induced potentiation of the acetylcholine-stimulated muscle contraction. These preliminary data suggest that the potentiating action of AF2 is not mediated by a cAMP pathway
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| Date Deposited | 18 Nov 2024 12:03 |
| Last Modified | 18 Nov 2024 12:03 |