Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device
Biocompatible and bio-based materials are an appealing resource for the pharmaceutical industry. Poly(glycerol-adipate) (PGA) is a biocompatible and biodegradable polymer that can be used to produce self-assembled nanoparticles (NPs) able to encapsulate active ingredients, with encouraging perspectives for drug delivery purposes. Starch is a versatile, inexpensive, and abundant polysaccharide that can be effectively applied as a bio-scaffold for other molecules in order to enrich it with new appealing properties. In this work, the combination of PGA NPs and starch films proved to be a suitable biopolymeric matrix carrier for the controlled release preparation of hydrophobic drugs. Dynamic Light Scattering (DLS) was used to determine the size of drug-loaded PGA NPs, while the improvement of the apparent drug water solubility was assessed by UV-vis spectroscopy. In vitro biological assays were performed against cancer cell lines and bacteria strains to confirm that drug-loaded PGA NPs maintained the effective activity of the therapeutic agents. Dye-conjugated PGA was then exploited to track the NP release profile during the starch/PGA nanocomposite film digestion, which was assessed using digestion models mimicking physiological conditions. The collected data provide a clear indication of the suitability of our biodegradable carrier system for oral drug delivery.
Item Type | Article |
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Uncontrolled Keywords | Biocompatible; Biomaterial; Drug delivery; Nanocomposites; Nanoparticles; Poly(glycerol-adipate); Polymer; Starch |
Subjects |
Physics and Astronomy(all) > Surfaces and Interfaces Materials Science(all) > Surfaces, Coatings and Films Materials Science(all) > Materials Chemistry |
Date Deposited | 26 Jul 2024 13:41 |
Last Modified | 26 Jul 2024 13:41 |
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Read more research from the creator(s):
- Vestri, Ambra
- Pearce, Amanda K.
- Cavanagh, Robert
- Styliari, Ioanna D.
- Sanders, Carlos
- Couturaud, Benoit
- Schenone, Silvia
- Taresco, Vincenzo
- Jakobsen, Rasmus R.
- Howdle, Steven M.
- Musumeci, Francesca
- Sagnelli, Domenico
Find work associated with the faculties and division(s):
- School of Life and Medical Sciences
- Department of Pharmacy, Pharmacology and Postgraduate Medicine
- Centre for Research into Topical Drug Delivery and Toxicology
- Department of Clinical, Pharmaceutical and Biological Science
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