Design, Synthesis and Antimicrobial Evaluation of the in vitro Efficacy of Novel Diketones
A series of novel diketones were designed and synthesised in an attempt to develop potent antimicrobial agents. Their structures were confirmed by spectroscopic techniques i.e. 1H and 13C-NMR, IR and LC-MS. The minimum inhibitory concentration (MIC) was determined against a wide range of bacteria using two fold micro broth dilution method. Among the test Compounds DK2, DK6, DK7, DK11, DK12, DK16 and DK17 were found to have excellent activity against all Gram positive bacteria with MIC values ranging 16-0.1μg/ml. The in vitro cytotoxity of all the active compounds was assessed by MTT clorimetric assay. The bioactive compounds exhibited IC50 values against Caco-2 cells rainging 64-8ug/ml
Item Type | Other |
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Date Deposited | 26 Jul 2024 14:56 |
Last Modified | 26 Jul 2024 14:56 |
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- Veterinary Science
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- School of Life and Medical Sciences
- Natural Product Chemistry and Drug Design
- Biosciences Research Group
- Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit
- Centre for Research in Mechanisms of Disease and Drug Discovery
- Department of Clinical, Pharmaceutical and Biological Science
- Centre for Health Services and Clinical Research
- Centre for Future Societies Research