Derivative-ratio spectrophotometric method for the determination of ternary mixture of aspirin, paracetamol and salicylic acid
A derivative spectrophotometric method was developed for the assay of a ternary mixture of aspirin (ASP), paracetamol (PAR) and salicylic acid (SAL). The method is based on the use of the first and second derivatives of the ratio spectra and measurement at zero-crossing wavelengths. The ratio spectra were obtained by dividing the absorption spectrum of the mixture by that of one of the components. The concentration of the other components are then determined from their respective calibration curves treated similarly. The described method was applied for the determination of these combinations in synthetic mixtures and dosage forms. The results obtained were accurate and precise.
Item Type | Article |
---|---|
Uncontrolled Keywords | Acetaminophen; Aspirin; Drug Combinations; Salicylic Acid; Spectrophotometry; Spectrophotometry, Ultraviolet |
Date Deposited | 26 Jul 2024 16:03 |
Last Modified | 26 Jul 2024 16:03 |
Explore Further
Read more research from the creator(s):
Find work associated with the faculties and division(s):