Ligands which bind weakly to vancomycin : Studies by 13C NMR spectroscopy
Pearce, C.M., Williams, D.H. and Gerhard, Ute
(1995)
Ligands which bind weakly to vancomycin : Studies by 13C NMR spectroscopy.
pp. 159-162.
ISSN 1472-779X
C NMR chemical shifts of vancomycin have been used to obtain the association constants for a number of ligands which bind weakly to the antibiotic. The change in these C chemical shifts upon stepwise addition of ligands provides evidence that the ligands bind in a manner analogous to natural cell-wall precursor analogues. The binding constants obtained are in good agreement with those determined earlier by other methods. Where the ligands are amino acids (glycine or alanine), a potential alkylammonium to amide carbonyl interaction does not promote binding.
Item Type | Article |
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Date Deposited | 26 Jul 2024 16:28 |
Last Modified | 26 Jul 2024 16:28 |
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