Modelling the oral cavity : In vitro and in vivo evaluations of buccal drug delivery systems
The delivery of drugs through the buccal mucosa has attracted much research interest over the past two decades and numerous approaches, both conventional and complex, have been developed in an attempt to deliver a variety of pharmaceutical compounds via the buccal route. However, the design of appropriate in vitro and in vivo methods to evaluate the behavior of these delivery systems is often ignored. This review aims to outline the progress in the in vitro and in vivo modeling of buccal drug delivery and provide a critical review of currently used methods. The development of a range of in vitro methods is outlined including disintegration/dissolution testing, in vitro mucoadhesion tests, in vitro residence time evaluation and permeability studies. The suitability of commonly used animal models for in vivo evaluation is also discussed and the physiological comparison of the animal oral cavity with that of a human's is described. --------------------------------------------------------------------------------
Item Type | Other |
---|---|
Uncontrolled Keywords | Buccal Mucosa; Buccal Drug Delivery System; In vitro–in vivo correlation; Mucoadhesion; Epithelial cell culture |
Date Deposited | 26 Jul 2024 16:28 |
Last Modified | 26 Jul 2024 16:28 |
Explore Further
Read more research from the creator(s):
Find work associated with the faculties and division(s):
- Department of Pharmacy
- Health & Human Sciences Research Institute
- Centre for Research into Topical Drug Delivery and Toxicology
- Pharmaceutics
- Skin and Nail Group
- Airway Group
- Bioadhesive Drug Delivery Group
- Nanopharmaceutics
- Modified Release Dosage Forms
- Pharmaceutical Analysis and Product Characterisation
- Toxicology