Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection
Baines, Simon D., Freeman, Jane and Wilcox, M. H.
(2009)
Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection.
pp. 2202-4.
ISSN 1098-6596
The efficacy of tolevamer, a nonantimicrobial styrene derivative toxin-binding agent, in treating simulated Clostridium difficile infection in an in vitro human gut model was investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by C. difficile, reflecting poor efficacy observed in recent phase III clinical trials.
Item Type | Article |
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Date Deposited | 26 Jul 2024 16:42 |
Last Modified | 26 Jul 2024 16:42 |
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